TREATMENT OF HYPERTHYROIDISM WITH RADIOIODINE: ADJUNCTIVE THERAPY WITH ANTITHYROID DRUGS RECONSIDERED
Identifieur interne : 003189 ( Main/Exploration ); précédent : 003188; suivant : 003190TREATMENT OF HYPERTHYROIDISM WITH RADIOIODINE: ADJUNCTIVE THERAPY WITH ANTITHYROID DRUGS RECONSIDERED
Auteurs : B. Velkeniers [Belgique] ; L. Vanhaelst [Belgique] ; R. Cytryn [Belgique] ; M. H. Jonckheer [Belgique]Source :
- The Lancet [ 0140-6736 ] ; 1988.
English descriptors
- Teeft :
- Adjunctive therapy, Antithyroid, Antithyroid antibodies, Antithyroid drugs, Asthma, Control groups, First year, Greenwood, Histocompatibility antigen, Hyperthyroid patients, Hyperthyroidism, Hypothyroidism, Lower incidence, Lymphocyte, Lymphocyte activation, Malaria, Malaria control, Normal range, Peripheral blood, Radioactive iodine, Radioiodine, Radioiodine therapy, Relapse, Standard doses, Thyroid function, Village health workers.
Abstract
Abstract: To assess the value of antithyroid drugs as an adjunct to radioactive iodine for the treatment of hyperthyroidism the incidence of relapse or hypothyroidism after a mean follow-up of 5 1/2 years (range 2-7 years) was reviewed retrospectively for 206 patients, some treated with and others without antithyroid drugs after radioiodine therapy. Allocation to treatment group had been random, and both groups were similar in all respects except for the adjunctive treatment with antithyroid drugs. All doses of 131I had been calculated by one physician. Compared with those who received 131I alone, those starting on antithyroid drugs within 8 days after 131I had a lower incidence of hypothyroidism but a higher incidence of early post-treatment recurrence or persistence of hyperthyroidism, and a considerably lower incidence of remission.
Url:
DOI: 10.1016/S0140-6736(88)91950-2
Affiliations:
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Jonckheer</name><affiliation wicri:level="3"><country xml:lang="fr">Belgique</country><wicri:regionArea>Departments of Endocrinology and Radioisotopes, Academic Hospital VUB, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">The Lancet</title><title level="j" type="abbrev">LANCET</title><idno type="ISSN">0140-6736</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1988">1988</date><biblScope unit="volume">331</biblScope><biblScope unit="issue">8595</biblScope><biblScope unit="page" from="1127">1127</biblScope><biblScope unit="page" to="1129">1129</biblScope></imprint><idno type="ISSN">0140-6736</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0140-6736</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Adjunctive therapy</term><term>Antithyroid</term><term>Antithyroid antibodies</term><term>Antithyroid drugs</term><term>Asthma</term><term>Control groups</term><term>First year</term><term>Greenwood</term><term>Histocompatibility antigen</term><term>Hyperthyroid patients</term><term>Hyperthyroidism</term><term>Hypothyroidism</term><term>Lower incidence</term><term>Lymphocyte</term><term>Lymphocyte activation</term><term>Malaria</term><term>Malaria control</term><term>Normal range</term><term>Peripheral blood</term><term>Radioactive iodine</term><term>Radioiodine</term><term>Radioiodine therapy</term><term>Relapse</term><term>Standard doses</term><term>Thyroid function</term><term>Village health workers</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: To assess the value of antithyroid drugs as an adjunct to radioactive iodine for the treatment of hyperthyroidism the incidence of relapse or hypothyroidism after a mean follow-up of 5 1/2 years (range 2-7 years) was reviewed retrospectively for 206 patients, some treated with and others without antithyroid drugs after radioiodine therapy. Allocation to treatment group had been random, and both groups were similar in all respects except for the adjunctive treatment with antithyroid drugs. All doses of 131I had been calculated by one physician. Compared with those who received 131I alone, those starting on antithyroid drugs within 8 days after 131I had a lower incidence of hypothyroidism but a higher incidence of early post-treatment recurrence or persistence of hyperthyroidism, and a considerably lower incidence of remission.</div></front></TEI><affiliations><list><country><li>Belgique</li></country><region><li>Région de Bruxelles-Capitale</li></region><settlement><li>Bruxelles</li></settlement></list><tree><country name="Belgique"><region name="Région de Bruxelles-Capitale"><name sortKey="Velkeniers, B" sort="Velkeniers, B" uniqKey="Velkeniers B" first="B." last="Velkeniers">B. Velkeniers</name></region><name sortKey="Cytryn, R" sort="Cytryn, R" uniqKey="Cytryn R" first="R." last="Cytryn">R. Cytryn</name><name sortKey="Jonckheer, M H" sort="Jonckheer, M H" uniqKey="Jonckheer M" first="M. H." last="Jonckheer">M. H. Jonckheer</name><name sortKey="Vanhaelst, L" sort="Vanhaelst, L" uniqKey="Vanhaelst L" first="L." last="Vanhaelst">L. Vanhaelst</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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